May 30, 2022

Radiotherapy using Geant4 Simulations

“Its palliation is a daily task, its cure a fervent hope.” -William Castle, describing leukemia in 1950.

Abstract

Radiation therapy is one of the the most widely used methods for cancer treatments after surgery and chemotherapy. High doses of radiations are used to kill cancer cells. In this study, depth dose for six prospective radiations has been plotted and analysed using Geant4 Simulation Toolkit, so we can compare and find the range of applications of each radiation by looking at their respective dose peaks. Studying depth dose plots for these different radiations in depth can lend us several insights into the nature of interaction and impact of these radiations in human body, and how we can make use of them in necessary real life medical treatments. Geant4 simulations offer us the freedom to modify several parameters and analyse their impact with such ease that would not have been possible in real life. By making use of this toolkit we can observe the depth dose behavior of different radiations and determine the exact range of energies for each radiation at which peaks are obtained. Finding the precise position and height of Bragg peak for proton beam through Geant4 simulations could make it easier to form the right Treatment Plan for Proton Therapy in order to be able to send radiations that hit at the precise tumor position with right energy, causing negligible harm to surrounding healthier tissue, thus attempting to make radiotherapy a safer and trustworthy option for cancer treatment.

Electron

Energy deposition curves of electrons of different energies ranging from 100eV to 100MeV along 5 cm deep water. Peak obtained for 1 MeV electrons, depositing 350 eV at 1.4 mm.

Positron

Energy deposition curves for positrons of energies ranging from 100 keV to 100 MeV along 5 cm deep water. Peak obtained for 1 MeV positrons at 1.5 mm, deposit of 350 keV energy.

Gamma

Energy deposition curves for gamma of energies ranging from 100 eV to 100 keV along 10 cm deep water.

Proton

Energy deposition curves for proton of energies ranging from 100 keV to 1000 MeV along 10 cm deep water. Peeks obtained for energies ranging between 10 MeV to 100 MeV. Upto 5 MeV can be deposited at a site 8 cm deep in body.

Alpha

Energy deposition curves for Alpha particle of energy ranging from 100 to 400 MeV. Peaks obtained for whole range, the highest one for 300 MeV deposits about 28 MeV of energy at 4.6 cm.

Carbon-12

Energy deposition curves for C12 ion of energies ranging from 0.5 to 3 GeV. Peaks obtained for energy ranging from 0.5 GeV to 2.5 GeV. Upto 140 MeV of energy can be deposited at a site as deep as 9 cm inside the body.